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PTH-related Peptide

PTHrP Parathyroid Hormone-related Protein
EDTA plasma (on ice, process promptly) pmol/L

About this test

Causes hypercalcaemia of malignancy by mimicking PTH at peripheral receptors. PTH is suppressed. Found in squamous cell carcinoma, renal carcinoma, breast cancer, and others.

Reference Ranges

Sex Age Range Notes
All ≥ 18 yrs < 1.5 Undetectable or very low in normal individuals

Clinical Interpretation

Low / Decreased
Undetectable — PTHrP-mediated hypercalcaemia excluded.
High / Increased
Elevated — malignancy-associated hypercalcaemia (humoral). Confirm with imaging to identify primary tumour.

Related Tests

Albumin Adjusted Calcium
Specimen
EDTA plasma (on ice, process promptly)
Reporting Unit
pmol/L
Category
⚗️ Endocrinology

⚠ Clinical Note
Reference ranges are indicative. Always interpret results in the context of the individual patient and local laboratory reference intervals, which may vary.