Total Haemolytic Complement

CH50 CH100 Total Complement Activity
Serum (SST, process promptly) U/mL

About this test

Functional assay measuring the ability of serum complement to lyse sensitised sheep erythrocytes. Reduced if any classical pathway component is deficient or consumed.

Reference Ranges

Sex Age Range Notes
All ≥ 18 yrs 41 – 90 Adult (highly lab-dependent)

Clinical Interpretation

Low / Decreased
Classical pathway deficiency (C1q, C1r/s, C4, C2, C3), complement consumption (SLE, infective endocarditis), hereditary angioedema.
Specimen
Serum (SST, process promptly)
Reporting Unit
U/mL

⚠ Clinical Note
Reference ranges are indicative. Always interpret results in the context of the individual patient and local laboratory reference intervals, which may vary.