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Anti-Cyclic Citrullinated Peptide

Anti-CCP ACPA Anti-citrullinated protein antibody
Serum (SST) U/mL

About this test

Highly specific for rheumatoid arthritis (specificity >95%). Present early, sometimes before clinical arthritis. Predicts more erosive disease.

Reference Ranges

Sex Age Range Notes
All ≥ 18 yrs < 20 Positive ≥20 U/mL

Clinical Interpretation

Low / Decreased
Seronegative for anti-CCP makes RA less likely, but does not exclude.
High / Increased
Rheumatoid arthritis (highly specific); rarely in other inflammatory arthritides.

Related Tests

Rheumatoid Factor
Specimen
Serum (SST)
Reporting Unit
U/mL
Category
🛡️ Immunology

⚠ Clinical Note
Reference ranges are indicative. Always interpret results in the context of the individual patient and local laboratory reference intervals, which may vary.