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PAPP-A

Pregnancy-Associated Plasma Protein A PAPP-A
Serum (SST; 10–13+6 weeks gestation) IU/L or MoM

About this test

Metalloproteinase produced by placenta. Measured at 10–14 weeks as part of first-trimester combined screening for trisomy 21, 18, and 13. Low PAPP-A also associated with adverse pregnancy outcomes.

Reference Ranges

Sex Age Range Notes
Female ≥ 18 yrs See notes Reported as MoM (multiples of median); <0.4 MoM indicates increased risk

Clinical Interpretation

Low / Decreased
Low (<0.4 MoM) — increased risk of trisomy 21, 18, 13, miscarriage, IUGR, pre-eclampsia.
Specimen
Serum (SST; 10–13+6 weeks gestation)
Reporting Unit
IU/L or MoM
Category
🔄 Hormones

⚠ Clinical Note
Reference ranges are indicative. Always interpret results in the context of the individual patient and local laboratory reference intervals, which may vary.