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Syphilis (TPPA)

TPPA Treponema pallidum Particle Agglutination Syphilis Serology TPHA
Serum (SST) Positive/Negative

About this test

Treponemal-specific test for Treponema pallidum antibodies. Remains positive lifelong after treated infection. Used alongside non-treponemal tests (VDRL/RPR) to monitor treatment.

Reference Ranges

Sex Age Range Notes
All All ages See notes Negative is normal; titre reported if positive

Clinical Interpretation

Low / Decreased
Negative — syphilis not detected (repeat if high suspicion and early infection).
High / Increased
Positive — past or current syphilis. Quantitative non-treponemal test (VDRL/RPR) required to assess activity and treatment response.
Specimen
Serum (SST)
Reporting Unit
Positive/Negative
Category
🦠 Microbiology

⚠ Clinical Note
Reference ranges are indicative. Always interpret results in the context of the individual patient and local laboratory reference intervals, which may vary.