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Anti-tTG IgA

Anti-tissue Transglutaminase IgA tTG-IgA Anti-tTG
Serum (SST) U/mL

About this test

Most sensitive and specific first-line serological test for coeliac disease. Must always be interpreted alongside total serum IgA (false negative in IgA deficiency).

Reference Ranges

Sex Age Range Notes
All ≥ 18 yrs < 10 Negative <10; equivocal 10–15; positive >15 (perform on gluten-containing diet)

Clinical Interpretation

Low / Decreased
Negative — coeliac disease unlikely if on gluten-containing diet and no IgA deficiency.
High / Increased
Positive — highly suggestive of coeliac disease. If >10× ULN, duodenal biopsy may be deferred in adults per ESPGHAN criteria (children only by most guidelines).
Specimen
Serum (SST)
Reporting Unit
U/mL
Category
🛡️ Immunology

⚠ Clinical Note
Reference ranges are indicative. Always interpret results in the context of the individual patient and local laboratory reference intervals, which may vary.